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JOURNAL ARTICLE

Multiple choices for HIV therapy with integrase strand transfer inhibitors

Francois Raffi, Mark A Wainberg
Retrovirology 2012 December 19, 9: 110
23253887
Two integrases inhibitors, raltegravir and elvitegravir, have now been approved by regulatory agencies for use in the treatment of HIV-infected patients; and the approval of a third such drug, dolutegravir, is expected during 2013 on the basis of several phase 3 clinical trials. The advent of this new class of antiretroviral (ARV) medications represents a major advance in the management of HIV infection, and each of these three drugs can be expected to continue to be an important component of ARV combination regimens.

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