Prevalence and associations of the use of proton-pump inhibitors in nursing homes: a cross-sectional study

Philipe de Souto Barreto, Maryse Lapeyre-Mestre, Céline Mathieu, Christine Piau, Catherine Bouget, Françoise Cayla, Bruno Vellas, Yves Rolland
Journal of the American Medical Directors Association 2013, 14 (4): 265-9

OBJECTIVES: Very scarce information is available about the use of proton-pump inhibitors (PPI) in nursing homes (NH). This study investigated the factors associated with PPI use among NH residents.

DESIGN: Cross-sectional

SETTING: One hundred seventy-five NHs in Midi-Pyrénées region, South-Western France.

PARTICIPANTS: Data was collected for 6275 NH residents. Participants (73.7% women) were aged 86 years (± 8.2).

MEASUREMENTS: NH staff sent participants' drug prescriptions to research team; they also recorded information on residents' health characteristics. A binary logistic regression was performed on PPI use.

RESULTS: PPI use was highly prevalent (n = 2 370, ie, 37.8%). Whilst peptic ulcer (OR 4.741; 95% CI 3.647-6.163) and nonsteroidal anti-inflammatory drugs (OR 2.124; 95% CI 1.528-2.951) were important indicators of PPI use, they explained just a small fraction of PPI prescriptions; most prescriptions were probably inappropriately related to a general condition of health vulnerability, reflected by polypharmacy and comorbidities.

CONCLUSIONS: Vulnerable people take PPIs more often in NHs. Physicians must be aware about the health risks possibly induced by inappropriate PPI use when prescribing these drugs for NH residents.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"