[Abnormal plasticity and drug effect in Parkinson's disease]

Hiroyuki Enomoto, Yoshikazu Ugawa
Rinshō Shinkeigaku, Clinical Neurology 2012, 52 (11): 1204-6
The repetitive transcranial magnetic stimulation (rTMS) has been studied as a method to induce plasticity changes in the human brain. And rTMS is expected as a therapeutic tool for Parkinson's disease, depression, intractable pain and others. We reported a new rTMS protocol, quadripulse stimulation (QPS), is more effective. QPS consists of repeated trains of four monophasic TMS pulses separated by inter-stimulus intervals of 5 ms (QPS-5) and 50 ms (QPS-50), inducing bidirectional motor cortical plasticity in an ISI dependent. QPS-5 leads to the potentiation effect. QPS-50 leads to a depression effect. We investigated the changes of plasticity induced by QPS in patients with Parkinson's disease and the healthy volunteer with oral administration of levodopa. In patients with Parkinson's disease the effect of QPS-5 and QPS-50 was attenuated at Off period. However, when the On period it was recovered. In healthy subjects, effect of QPS was enhanced by levodopa, both QPS-5 and QPS-50.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"