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Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.

Rita Nemr, Amira Turki, Akram Echtay, Ghadeer S Al-Zaben, Hoda S Daher, Noha A Irani-Hakime, Sose H Keleshian, Wassim Y Almawi
Diabetes Research and Clinical Practice 2012 December
We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.

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