Hypokalemic paralysis as a presenting manifestation of primary Sjögren's syndrome: A report of two cases

Deepak Khandelwal, Saptarshi Bhattacharya, Rajesh Khadgawat, Satbir Kaur, Nikhil Tandon, Ariachery C Ammini
Indian Journal of Endocrinology and Metabolism 2012, 16 (5): 853-5
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by a progressive lymphocytic infiltration of the exocrine glands with varying degrees of systemic involvement. Overt or latent renal tubular acidosis (RTA), caused by tubulointerstitial nephropathy, is a common extraglandular manifestation of pSS. Hypokalemic paralysis is a well known, albeit rare complication of severe distal RTA from any cause. Cases of pSS manifesting for the first time as hypokalemic paralysis caused by distal RTA have been rarely reported. We herein present our experience of two cases, who presented to us for evaluation of hypokalemic paralysis and on work up found evidence of distal RTA, which on further work up found to be secondary to pSS. A high index of suspicion for pSS should be kept in all patients with hypokalemic paralysis.

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