We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Protection against butyl p-hydroxybenzoic acid induced oxidative stress by Ocimum sanctum extract in mice liver.
Acta Poloniae Pharmaceutica 2012 September
Prime focus of the present investigation was to evaluate hepatoprotective potency of Ocimum sanctum (O. sanctum) aqueous extract against butyl p-hydroxybenzoic acid (butylparaben) toxicity in mice. Oral treatment of butylparaben (1320 mg/kg b.w./day) to mice for 30 days resulted in significant (p < 0.05) elevation in hepatic lipid peroxidation, which could be due to significant (p < 0.05) reduction in non-enzymatic (glutathione and total ascorbic acid) antioxidant contents and enzymatic (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione transferase) antioxidants activities. Co-treatment of O. sanctum extracts in three different doses (100, 200 and 300 mg/kg b.w./day) resulted in significant (p < 0.05) reduction in butylparaben-induced hepatic changes. Oral administration of O. sanctum with butylparaben resulted in dose-dependent and significant (p < 0.05) reduction in lipid peroxidation as compared to butylparaben alone treated group. Similarly, all three doses of O. sanctum reduced butylparaben-induced changes in non-enzymatic and enzymatic antioxidants. The effect was significant (p < 0.05) and dose-dependent. All three doses of O. sanctum ameliorated butylparaben-induced changes, showing maximum protection at 300 mg/kg b.w./day dose. Results of present study indicate that butylparaben-induced hepatotoxicity involves its ability to induce oxidative stress, whereas antihepatotoxic effect of O. sanctum was mainly due to its antioxidative potency.
Full text links
Related Resources
Trending Papers
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Anti-Arrhythmic Effects of Heart Failure Guideline-Directed Medical Therapy and Their Role in the Prevention of Sudden Cardiac Death: From Beta-Blockers to Sodium-Glucose Cotransporter 2 Inhibitors and Beyond.Journal of Clinical Medicine 2024 Februrary 27
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app