JOURNAL ARTICLE

High RSF-1 expression correlates with poor prognosis in patients with gastric adenocarcinoma

Ben-Shun Hu, Hai-Feng Yu, Gao Zhao, Tian-Zhou Zha
International Journal of Clinical and Experimental Pathology 2012, 5 (7): 668-73
22977663

AIM: To investigate the expression and prognostic significance of RSF-1 in gastric adenocarcinoma.

METHODS: RSF-1 expression was analyzed using immunohistochemical staining on tissue samples from a consecutive series of 287 gastric adenocarcinoma patients who underwent tumor resections between 2003 and 2006.The relationship between RSF-1 expression, clinicopathological factors, and patient survival was investigated.

RESULTS: Immunohistochemical staining indicated that RSF-1 is highly expressed in 52.6% of gastric adenocarcinomas. RSF-1 expression levels were closely associated with tumor size, histological differentiation, tumor stage, and lymph node involvement. Kaplan-Meier survival analysis showed that high RSF-1 expression exhibited a significant correlation with poor prognosis for gastric adenocarcinoma patients. Multivariate analysis revealed that RSF-1 expression is an independent prognostic parameter for the overall survival rate of gastric adenocarcinoma patients.

CONCLUSION: Our data suggest that RSF-1 plays an important role in gastric adenocarcinoma progression and that high RSF-1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients.

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