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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production.
Fitoterapia 2012 December
A phytochemical investigation of the whole plants of Ajuga decumbens led to the isolation of three new (1, 2a, and 2b) and three known (3a-3c) neo-clerodane diterpenes. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HR-ESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of the six diterpenes were evaluated and compounds 2a, 2b, and 3a showed inhibitory effects.
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