JOURNAL ARTICLE

ER stress and autophagy contribute to CsA-induced death of malignant glioma cells

Iwona Anna Ciechomska, Bozena Kaminska
Autophagy 2012, 8 (10): 1526-8
22910018
Cyclosporine A (CsA), which revolutionized transplantology due to its ability to block the activation of lymphocytes and other immune system cells, triggers autophagy in malignant glioma cell lines via stimulation of endoplasmic reticulum (ER) stress. We also found that autophagy serves as a protective mechanism against CsA toxicity.

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