[Association of transforming growth factor-β1 with pathological grading of intervertebral disc degeneration]

Yang Yang, Xiaofeng He, Yanhao Li, Jianyu Feng, Huajin Pang, Jiangyun Wang, Qing Liu
Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University 2012, 32 (6): 897-900

OBJECTIVE: To explore the role of transforming growth factor-β1 (TGF-β1) in intervertebral disc degeneration and its association with the pathological grading of disc degeneration.

METHODS: Normal and degenerative intervertebral disc tissues were collected were classified into 5 grades of increasing degenerative changes. HE staining, immunohistochemistry, TUNEL staining and RT-PCR were used to detect the expression of TGF-β1 in the disc tissues.

RESULTS: Immunohistochemistry and RT-PCR showed positive expressions of TGF-β1 and Bcl-2 in normal disc tissues, where Bax was expressed at have a trace level. In the degenerative disc tissues, TGF-β1 expression increased with the pathological grades; the expression levels of TGF-β1 showed significant differences between degenerative and normal tissues and between grade IV and grade I disc tissues (P<0.01).

CONCLUSION: TGF-β1 is an important factor participating in the disc degeneration and its expression level is closely related to the pathological grade of degenerative discs.

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