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Near-infrared light-responsive intracellular drug and siRNA release using au nanoensembles with oligonucleotide-capped silica shell.

Yi-Ting Chang, Pei-Yi Liao, Hwo-Shuenn Sheu, Yu-Jui Tseng, Fong-Yu Cheng, Chen-Sheng Yeh
Advanced Materials 2012 July 4
Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery.

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