Epigenetic modulation by TFII-I during embryonic stem cell differentiation

Dashzeveg Bayarsaihan, Aleksandr V Makeyev, Badam Enkhmandakh
Journal of Cellular Biochemistry 2012, 113 (10): 3056-60
TFII-I transcription factors play an essential role during early vertebrate embryogenesis. Genome-wide mapping studies by ChIP-seq and ChIP-chip revealed that TFII-I primes multiple genomic loci in mouse embryonic stem cells and embryonic tissues. Moreover, many TFII-I-bound regions co-localize with H3K4me3/K27me3 bivalent chromatin within the promoters of lineage-specific genes. This minireview provides a summary of current knowledge regarding the function of TFII-I in epigenetic control of stem cell differentiation.

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