Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease

Koa Hosoki, Masahiro Hirayama, Gail M Kephart, Hirohito Kita, Mizuho Nagao, Hiromasa Uchizono, Hidemi Toyoda, Yuko Senba, Yu Imai, Yoshihiro Komada, Toshiaki Ihara, Takao Fujisawa
International Archives of Allergy and Immunology 2012, 158 Suppl 1: 70-4
Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5- and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.

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