[CSF biomarkers in children with acute encephalopathy syndrome]

Naoyuki Tanuma
Nihon Rinsho. Japanese Journal of Clinical Medicine 2012, 70 (5): 887-92
Viral infection-associated acute encephalopathy in children is a clinical syndrome with high mortality and neurological sequelae. Its main symptoms of acute phase are impaired consciousness and convulsive status epilepticus with hyperpyrexia. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is characterized clinically by biphasic seizures and late MRI abnormalities such as reduced subcortical diffusion. Despite the intensive care, patients with AESD often have severe neurological impairment and it is very difficult to distinguish AESD from febrile seizures in the early phase. Although there is currently no specific biomarker for early diagnosis of acute encephalopathy syndrome, we believe tau protein and 8-hydroxy-2'-deoxyguanosine (8-OHdG) are potential biomarkers which could be useful in following the clinical course and monitoring the efficacy of therapies.

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