We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
REVIEW
Epigenetics and eating disorders.
PURPOSE OF REVIEW: Eating disorders are complex psychiatric disorders in which genes, environment, and gene-environment interactions (G×E) have a role. Such G×E may occur in adulthood or during development. They may also be modified by factors such as (mal)nutrition or stress and this may result in acute or long-term epigenetic modifications. This review discusses the potential for recent developments in epigenetics to address ongoing aetiological issues in eating disorders.
RECENT FINDINGS: Epigenetic studies in eating disorders have focussed on the DNA methylation status of promoter regions of candidate genes: differences have been reported between people with eating disorders and healthy controls, and between subtypes of eating disorders. Animal studies related to eating disorders have focussed on understanding the acute and long-term effects of environmental manipulation on epigenetic changes and on the resultant phenotypes: these studies are promising, but they have also identified some of the complexity of epigenetic processing.
SUMMARY: Because of the difficulties in obtaining brain samples, epigenetic studies in eating disorders (like in other psychiatric illnesses) have used peripheral tissues, usually blood: this raises various problems. It is likely, therefore, that in the immediate future, animal, rather than human studies will guide the progress in epigenetics studies of eating disorders and other psychiatric disorders.
RECENT FINDINGS: Epigenetic studies in eating disorders have focussed on the DNA methylation status of promoter regions of candidate genes: differences have been reported between people with eating disorders and healthy controls, and between subtypes of eating disorders. Animal studies related to eating disorders have focussed on understanding the acute and long-term effects of environmental manipulation on epigenetic changes and on the resultant phenotypes: these studies are promising, but they have also identified some of the complexity of epigenetic processing.
SUMMARY: Because of the difficulties in obtaining brain samples, epigenetic studies in eating disorders (like in other psychiatric illnesses) have used peripheral tissues, usually blood: this raises various problems. It is likely, therefore, that in the immediate future, animal, rather than human studies will guide the progress in epigenetics studies of eating disorders and other psychiatric disorders.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app