Treatment of refractory intracranial hypertension with 23.4% saline in children with severe traumatic brain injury

Kazuma Nakagawa, Cherylee W J Chang, Matthew A Koenig, Mihae Yu, Sheri Tokumaru
Journal of Clinical Anesthesia 2012, 24 (4): 318-23
The safety and efficacy of osmotic therapy with mannitol and 3% saline in the pediatric head-injured population has been widely reported; the use of 23.4% saline in children for the treatment of refractory intracranial hypertension has not. The clinical and physiologic responses of multiple 23.4% saline boluses in two children with severe traumatic brain injury (TBI) are presented. No complications were associated with the use of 23.4% saline in either patient.

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