Nasal septal perforation from bevacizumab: a discussion of outcomes, management, and pharmacovigilance

Judi Anne B Ramiscal, Aminah Jatoi
Current Oncology Reports 2012, 14 (4): 307-10
To date, the published literature describes 18 reports of nasal septal perforation in cancer patients with the administration of bevacizumab. This complication was detected during post-marketing surveillance of bevacizumab. How should patients who develop this complication be managed? This discussion summarizes suggestions for management of bevacizumab-associated nasal septal perforation and, as relevant to healthcare providers, discusses some of the practical aspects of post-marketing pharmacovigilance.

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