Amphiphilic α-helix mimetics based on a benzoylurea scaffold

Sam Thompson, Andrew D Hamilton
Organic & Biomolecular Chemistry 2012 August 14, 10 (30): 5780-2
The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

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