JOURNAL ARTICLE

High beam current operation of a PETtrace™ cyclotron for 18F- production

S Eberl, T Eriksson, O Svedberg, J Norling, D Henderson, P Lam, M Fulham
Applied Radiation and Isotopes 2012, 70 (6): 922-30
22476015
Upgrades and optimisation achieved 160 μA total target current operation of a GE PETtrace cyclotron in dual target mode for the routine production of [(18)F]FDG for >2 years. Approximately 900 GBq of (18)F(-) and >500 GBq of [(18)F]FDG can be produced routinely in a single production run, meeting the routine [(18)F]FDG requirements with our customer base and achieving economies of scale. Production of >1 TBq of (18)F(-) in a single run was achieved. Reliability, saturation and synthesis yields were not adversely affected.

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