From spirolactam mixtures to regioisomerically pure 5- and 6-rhodamines: a chemodosimeter-inspired strategy

Haibo Yu, Yi Xiao, Haiying Guo
Organic Letters 2012 April 20, 14 (8): 2014-7
Inspired by the ring-open reaction of rhodamine spriolactams as typical chemodosimeters, a general strategy is proposed to conveniently and efficiently synthesize isomerically pure 5- and 6-R-tetramethylrhodamine on a larger scale.

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