Cytotoxic diterpenoids from Sapium insigne

Hong-Bing Liu, Hua Zhang, Jin-Hai Yu, Cheng-Hui Xu, Jian Ding, Jian-Min Yue
Journal of Natural Products 2012 April 27, 75 (4): 722-7
Chemical investigation into the twigs and leaves of Sapium insigne afforded seven new diterpenoids, sapinsignoids A-G (1-7), together with 10 known diterpenoids. The structures of 1-7 were assigned on the basis of detailed spectroscopic analysis and chemical degradation. Compounds 1-4 exhibited significant cytotoxicity against the A-549 tumor cell line (IC(50) 0.2-1.8 μM), while compounds 1-3 showed moderate cytotoxicity against the HL-60 cell line (IC(50) 2.7-6.5 μM).

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