We have located links that may give you full text access.
JOURNAL ARTICLE
REVIEW
Filaggrin mutations and atopy: consequences for future therapeutics.
Expert Review of Clinical Immunology 2012 Februrary
Filaggrin is a key component of the epidermal differentiation complex of the stratum corneum in the epidermal layer of human skin. Loss-of-function mutations in filaggrin have been described in patients with atopic eczema and are associated with an increased risk of atopic sensitization in these individuals. Atopic eczema is the first stage of the atopic march that describes the phenomenon of increased rates of allergic rhinitis and allergic asthma observed in individuals with early atopic dermatitis. The skin barrier disruptions of atopic eczema associated with loss-of-function mutations in filaggrin are thought to provide a nidus for allergic sensitization to food and aeroallergens, which can then lead to increased allergic disease. It is on this foundation that therapies aimed at restoration of barrier function are thought to play a role, not only in the effective treatment of atopic eczema, but also in the prevention of further allergic disease development.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app