LETTER

Haemolytic-uraemic syndrome during severe lupus nephritis: efficacy of plasma exchange

M Samson, S Audia, V Leguy, S Berthier, N Janikashvili, L Martin, B Bonnotte, B Lorcerie
Internal Medicine Journal 2012, 42 (1): 95-8
22276560
Systemic lupus erythematosus (SLE) has been described as a cause of thrombotic microangiopathy, especially thrombotic thrombocytopenic purpura (TTP). Haemolytic-uraemic syndrome (HUS) is less frequent in SLE. We report a case of such an association during an episode of severe lupus nephritis in a young woman, who was successfully treated with steroids, cyclophosphamide and especially plasma exchange with plasma replacement. This report highlights the importance of recognising atypical HUS in SLE patients by looking for schistocytes in case of haemolytic anemia with a negative antiglobulin test, in order to begin plasma exchange.

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