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Is blood ammonia influenced by kidney function? A prospective study.

Muhammad Imran, Yaser Shah, Seema Nundlall, Norman B Roberts, Matthew Howse
Clinical Biochemistry 2012 March
BACKGROUND: We have investigated whether blood ammonia is increased with worsening CKD.

METHODS: Fifty eight subjects with a range of CKD were recruited for analysis of plasma ammonia and other electrolytes.

RESULTS: The concentrations of plasma ammonia were all within the normal reference range and there was no correlation between ammonia and CKD without any effect of dialysis.

CONCLUSIONS: Blood ammonia is not elevated in or related to the severity of chronic kidney disease.

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