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JOURNAL ARTICLE
REVIEW

HIV treatment as prevention and HPTN 052

Myron S Cohen, Marybeth McCauley, Theresa R Gamble
Current Opinion in HIV and AIDS 2012, 7 (2): 99-105
22227585

PURPOSE OF REVIEW: This review summarizes the development and implementation of a large clinical trial, HIV Prevention Trials Network (HPTN) 052, whose initial results were recently presented and published.

RECENT FINDINGS: A randomized, clinical trial demonstrated that antiretroviral therapy reduces the sexual transmission of HIV in HIV-serodiscordant couples by more than 96%. The logistical challenges in preparing for and conducting such a trial were considerable.

SUMMARY: HPTN 052 required many years of preparation, considerable collaboration between National Institute of Health and six pharmaceutical companies, and careful ongoing consideration of a large number of ethical issues. HPTN 052 revealed the magnitude of benefit when using antiretroviral therapy to prevent the transmission of HIV, and served as proof of a concept. The results have proven central to the development of new global HIV-prevention efforts.

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