Development of FRET-based ratiometric fluorescent Cu2+ chemodosimeters and the applications for living cell imaging

Lin Yuan, Weiying Lin, Bin Chen, Yinan Xie
Organic Letters 2012 January 20, 14 (2): 432-5
Coumarin-rhodamine-based compounds 1a,b were rationally designed and synthesized as novel FRET ratiometric fluorescent chemodosimeters. Ratiometric chemodosimeters 1a,b exhibit several favorable features, including a large variation in the emission ratio, well-resolved emission peaks, high sensitivity, high selectivity, low cytotoxicity, and good cell membrane permeability. Importantly, these excellent attributes enable us to demonstrate ratiometric imaging of Cu(2+) in living cells by using these novel ratiometric fluorescent chemodosimeters.

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