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JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL

Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function

Ricardo Mendes Martins, Regina Helena Alves Fonseca, Marta Maria Turano Duarte, Vaneska Spinelli Reuters, Márcia Martins Ferreira, Cloyra Almeida, Alexandru Buescu, Patrícia de Fátima dos Santos Teixeira, Mario Vaisman
Arquivos Brasileiros de Endocrinologia e Metabologia 2011, 55 (7): 460-7
22147094

OBJECTIVE: To evaluate the effects of levothyroxine (L-T4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (SH).

SUBJECTS AND METHODS: This was a randomized, double-blind, placebo-controlled study. Echocardiographic evaluation was carried out at baseline and one year after restoration of euthyroidism. Thirty-three women with SH were assigned to one of two groups (L-T4 or placebo).

RESULTS: The two groups had similar basal characteristics. There was a significant deterioration of left ventricular Tei index after one year of placebo use, which differed from the effect of L-T4 replacement (+0.086 ± 0.092 vs. -0.014 ± 0.012; p = 0.047). There was also a slight reduction in cardiac output and cardiac index with placebo use, which was not different from L-T4 effect.

CONCLUSION: Results suggest a positive impact of L-T4 replacement in cardiac function of middle-aged women with SH.

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