Despite the endemic nature of Entamoeba histolytica infection in the United States there is a lack of data on amebiasis-related mortality. We analyzed national death certificate data from 1990 to 2007 to assess the occurrence of amebiasis-related deaths and determine demographic and regional associations. A total of 134 deaths were identified. Mortality rates were highest in males, Hispanics, Asian/Pacific Islanders, and persons 75 years of age and older. An association with human immunodeficiency virus infection was also observed. A declining trend of amebiasis deaths was noted over the 18-year study period. Over 40% of fatal amebiasis cases occurred in residents of California and Texas. United States-born persons accounted for the majority of amebiasis deaths; however, all of the fatalities in Asian/Pacific Islanders and 60% of the deaths in Hispanics were in foreign-born individuals. Although uncommon, amebiasis-related deaths routinely occur in the United States.
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