JOURNAL ARTICLE

Clinical features and immunological markers of atopic dermatitis in elderly patients

Andrzej Bozek, Andreas Fisher, Barbara Filipowska, Bogdan Mazur, Jerzy Jarzab
International Archives of Allergy and Immunology 2012, 157 (4): 372-8
22122980

BACKGROUND: Atopic dermatitis (AD) is increasing among the elderly. Staphylococcus aureus colonization is one of the most important aggravating factors in AD.

OBJECTIVE: This study analyses the clinical features of AD in elderly patients and determines the pathogenic roles of staphylococcal superantigens in AD with low and high total IgE levels.

METHODS: S. aureus enterotoxin genes were evaluated using PCR. Additionally, S. aureus-specific IgE levels and peripheral blood lymphocyte profiles were assessed.

RESULTS: A total of 44 women and 77 men diagnosed with AD with a mean age of 68.92 ± 6.51 years were evaluated. In 17 (68%) patients with AD and low levels of total IgE, there was a positive correlation between the positive results for enterotoxin B, S. aureus-specific IgE antibodies and Th1 cytokine profiles (Spearman's rank correlation test, r = 0.89, p < 0.05).

CONCLUSION: Our results indicate that AD patients with low total IgE levels differ in immunopathogenesis from AD patients with high circulating levels of total IgE AD.

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