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JOURNAL ARTICLE

Constituents of Trigonostemon heterophyllus

Shi-Hui Dong, Hong-Bing Liu, Cheng-Hui Xu, Jian Ding, Jian-Min Yue
Journal of Natural Products 2011 December 27, 74 (12): 2576-81
22122667
Six new diterpenoids, 1-6, a new prenylated sesquiterpenoid, 7, and six known compounds were isolated from Trigonostemon heterophyllus. The structures of 1-7 were elucidated on the basis of NMR and MS analysis. The daphnane diterpenoids trigoheterins A (1) and B (2) possess a rare 4,6-oxetane moiety within this compound class, and trigoheteric acid methyl ester (6) is the first example of a 15,16-dinor-3,4-seco-cleistanthane. Trigoheterin E (5) exhibited cytotoxic activity against the HL-60 (IC₅₀) 1.8 μM) and A-549 (IC₅₀ 10.0 μM) human cancer cell lines.

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