[Changes in concentrations of tumor necrosis factor TNF and its soluble receptors type 1 (sTNF-r1) and type 2 (sTNF-R2) in serum of patients with ST-segment elevation myocardial infarction].

INTRODUCTION: Impairments of apoptosis process, called programmed cell death, are the basis of pathogenesis of cardiovascular disease, including myocardial infarction. The aim of our study was to estimation dynamic changes of Tumor Necrosis Factor (TNF) and soluble receptors for TNF: type 1 (sTNF-R1) and type 2 (sTNF-R2) levels in serum of patients with ST-segment elevation myocardial infarction.

MATERIAL AND METHODS: The study group consisted of 70 patients aged 42 to 75 (mean 58.3 +/- 7.6 years) with the confirmed first episode of the ST-segment elevation myocardial infarction. The analyzed material was blood obtained from patients at fourth time: I. - the time of admission, II. - after 12 hour, III. - after 24 hour and IV. - on 5th day. Serum TNF, sTNF-R1 and sTNF-R2 levels were performed with the use of the immunoenzymatic method ELISA.

RESULTS: The highest concentrations of TNF, sTNF-R1 and sTNF-R2 at a time of admission were observed. In the next examination dates level of studied parameters decreased: after 12 hours, after 24 hours and on 5th day.

CONCLUSIONS: In patients with myocardial infarction were observed intensify of apoptosis process, which associated with increased concentration of TNF, sTNF-R1 and sTNF-R2. The measurement of studied parameters might be usefulin monitoring of course myocardial infarction, which need more examinations.