Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan

Masato Tashiro, Koichi Izumikawa, Asuka Minematsu, Katsuji Hirano, Naoki Iwanaga, Shotaro Ide, Tomo Mihara, Naoki Hosogaya, Takahiro Takazono, Yoshitomo Morinaga, Shigeki Nakamura, Shintaro Kurihara, Yoshifumi Imamura, Taiga Miyazaki, Tomoya Nishino, Misuzu Tsukamoto, Hiroshi Kakeya, Yoshihiro Yamamoto, Katsunori Yanagihara, Akira Yasuoka, Takayoshi Tashiro, Shigeru Kohno
Antimicrobial Agents and Chemotherapy 2012, 56 (1): 584-7
We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates for itraconazole and posaconazole, respectively. Amphotericin B MICs of ≥2 μg/ml and micafungin minimum effective concentrations (MECs) of ≥16 μg/ml were recorded for two and one isolates, respectively.

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