OPEN IN READ APP
JOURNAL ARTICLE

Aggressive B cell lymphomas of the gastrointestinal tract: clinicopathologic and genetic analysis

Song-Yi Choi, Seok Jin Kim, Won Seog Kim, Kihyun Kim, Young-Hyeh Ko
Virchows Archiv: An International Journal of Pathology 2011, 459 (5): 495-502
22002677
Aggressive B cell lymphomas of the gastrointestinal tract include Burkitt lymphoma (BL), diffuse large B cell lymphoma, and B cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL. To investigate the clinical characters of DLBCL/BL of the gastrointestinal (GI) tract, 101 cases of aggressive B cell lymphoma of the GI tract were analyzed by immunohistochemistry and fluorescence in situ hybridization (FISH) using break apart probe for c-MYC gene. For cases with c-MYC rearrangement, additional FISH studies with MYC/IgH fusion probe, BCL2 break apart probe, and BCL6 break apart probe were performed. MYC rearrangement was detected in 23 of 101 cases of aggressive B cell lymphomas (22.5%). The cases with MYC rearrangement were divided into 14 BL, three DLBCL/BL, and six DLBCL. One of the three DLBCL/BL had double translocation for MYC and BCL6 gene. Clinically, DLBCL/BL of the GI tract was more akin to Burkitt lymphoma than it is to GI tract DLBCL with c-MYC rearrangement. The overall prognosis of patients with DLBCL/BL was the worst among aggressive B cell lymphomas. DLBCL/BL is uncommon category of B cell lymphoma in the GI tract with aggressive clinical course despite of intensive chemotherapy.

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
22002677
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"