Salinomycin can effectively kill ALDH(high) stem-like cells on gastric cancer

Qiao Ming Zhi, Xue Hua Chen, Jun Ji, Jia Nian Zhang, Jian Fang Li, Qu Cai, Bing Ya Liu, Qin Long Gu, Zheng Gang Zhu, Ying Yan Yu
Biomedicine & Pharmacotherapy 2011, 65 (7): 509-15
Salinomycin is a novel identified cancer stem cells (CSCs) killer. Higher ALDH activity represents CSCs characterization. Here, we screened ALDH activities on several gastric cancer cell lines and divided them into ALDH(high) and ALDH(low) gastric cancer groups. ALDH(high) cancer cells (NCI-N87 and SNU-1) disclosed more CSCs characteristics, such as higher levels of Sox2, Nanog and Nestin, more floating spheroid bodies, more colony formation and more resistance to conventional chemotherapeutic drugs 5-Fu and CDDP, compared to these parameters observed in ALDH(low) cancer cells (P<0.01). Importantly, ALDH(high) cancer cells are relatively sensitive to salinomycin when compared to ALDH(low) cancer cells (P<0.01). Our results confirmed ALDH as functional marker of CSCs population on gastric cancer. Salinomycin might be selective therapy for CSCs fraction, which is resistant to conventional anticancer drugs 5-Fu and CDDP.

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