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Posaconazole for chronic refractory coccidioidal meningitis.

Rebecca Schein, James Homans, Robert A Larsen, Michael Neely
Clinical Infectious Diseases 2011 December
Coccidioidal meningitis is a potentially lethal infection. Disease progression while taking fluconazole is a common complication and safe, effective, alternative treatments are limited. Posaconazole therapy resulted in symptomatic and laboratory improvement in 2 patients and clinical improvement in a third patient with chronic, previously unresponsive coccidioidal meningitis.

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