EUS-guided biliary drainage with transluminal stenting after failed ERCP: predictors of adverse events and long-term results

Do Hyun Park, Ji Woong Jang, Sang Soo Lee, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim
Gastrointestinal Endoscopy 2011, 74 (6): 1276-84

BACKGROUND: EUS-guided biliary drainage (EUS-BD) has been proposed as an effective alternative for percutaneous transhepatic biliary drainage (PTBD) after failed ERCP. To date, the risk factors for adverse events and long-term outcomes of EUS-BD with transluminal stenting (EUS-BDS) have not been fully explored.

OBJECTIVE: To evaluate risk factors for adverse events and long-term outcomes of EUS-BDS.

DESIGN: Prospective follow-up study.

SETTING: Tertiary-care academic center.

PATIENTS: This study involved 57 consecutive patients with malignant or benign biliary obstruction undergoing EUS-BDS after failed ERCP.

INTERVENTION: EUS-guided hepaticogastrostomy (EUS-HGS) and EUS-guided choledochoduodenostomy with transluminal stenting (EUS-CDS).

MAIN OUTCOME MEASUREMENTS: Risk factors for postprocedure and late adverse events and clinical outcomes of EUS-BDS.

RESULTS: The overall technical and functional success rates, respectively, in the EUS-BDS group were 96.5% (intention-to-treat, n = 55/57) and 89% (per-protocol, n = 49/55). Postprocedure adverse events developed after EUS-BDS in 11 patients (20%, n = 11/55). This included bile peritonitis (n = 2), mild bleeding (n = 2), and self-limited pneumoperitoneum (n = 7). In multivariate analysis, needle-knife use was the single risk factor for postprocedure adverse events after EUS-BDS (odds ratio 12.4; P = .01). A late adverse event in EUS-BDS was distal stent migration (7%, n = 4/55). The mean stent patencies with EUS-HGS and EUS-CDS were 132 days and 152 days, respectively.

LIMITATIONS: Single-operator performed, nonrandomized study.

CONCLUSION: EUS-HGS and EUS-CDS may be relatively safe and can be used as an alternative to PTBD after failed ERCP. Both techniques offer durable and comparable stent patency. The use of a needle-knife for fistula dilation in EUS-BDS should be avoided if possible.

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