We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
The prognostic value of tissue oxygen saturation in emergency department patients with severe sepsis or septic shock.
Emergency Medicine Journal : EMJ 2012 September
OBJECTIVES: To determine the derangement of muscle tissue oxygen saturation (StO(2)) in the early phase of emergency department (ED) sepsis management and its relationship to 30-day mortality in patients with severe sepsis or septic shock.
METHODS: A prospective cohort study conducted in the ED of a university hospital. Patients were included if they had a clinical diagnosis of severe sepsis or septic shock. Thenar muscle tissue StO(2) on arrival in the ED and its change with usual ED sepsis management was measured using near-infrared spectroscopy. A follow-up measurement was obtained after 24 h of treatment. All patients were followed for 30 days.
RESULTS: 49 patients were included, of which 24 (49%) died. There was no difference in mean StO(2) on arrival in the ED between survivors and non-survivors (72% vs 72%; p=0.97). Following ED treatment the mean StO(2) of survivors improved significantly to 78% (p<0.05) while StO(2) remained persistently low in non-survivors (p=0.94). Persistently low StO(2) (<75%) despite initial resuscitative treatment was associated with a twofold increase in mortality (RR of death 2.1%; 95% CI 1.2% to 3.5%).
CONCLUSION: Patients with severe sepsis/septic shock have abnormal muscle tissue StO(2) upon arrival in the ED. Inability to normalise StO(2) with ED sepsis management is associated with a poor outcome. The role of StO(2) as an early prognostic and potential therapeutic biomarker in severe sepsis or septic shock warrants further exploration.
METHODS: A prospective cohort study conducted in the ED of a university hospital. Patients were included if they had a clinical diagnosis of severe sepsis or septic shock. Thenar muscle tissue StO(2) on arrival in the ED and its change with usual ED sepsis management was measured using near-infrared spectroscopy. A follow-up measurement was obtained after 24 h of treatment. All patients were followed for 30 days.
RESULTS: 49 patients were included, of which 24 (49%) died. There was no difference in mean StO(2) on arrival in the ED between survivors and non-survivors (72% vs 72%; p=0.97). Following ED treatment the mean StO(2) of survivors improved significantly to 78% (p<0.05) while StO(2) remained persistently low in non-survivors (p=0.94). Persistently low StO(2) (<75%) despite initial resuscitative treatment was associated with a twofold increase in mortality (RR of death 2.1%; 95% CI 1.2% to 3.5%).
CONCLUSION: Patients with severe sepsis/septic shock have abnormal muscle tissue StO(2) upon arrival in the ED. Inability to normalise StO(2) with ED sepsis management is associated with a poor outcome. The role of StO(2) as an early prognostic and potential therapeutic biomarker in severe sepsis or septic shock warrants further exploration.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app