JOURNAL ARTICLE

Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort

Fuat Kurbanov, Mohamed Abdel-Hamid, Rachel Latanich, Jacquie Astemborski, Mostafa Mohamed, Nabiel Mh Mikhail, Mai El-Daly, Sherif El-Kafrawy, David L Thomas, Chloe L Thio
Journal of Infectious Diseases 2011, 204 (9): 1391-4
21933876
Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in those with spontaneous clearance (76.3% vs 57.9%; P = .0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa.

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