JOURNAL ARTICLE
REVIEW

Treating Clostridium difficile infection with fecal microbiota transplantation

Johan S Bakken, Thomas Borody, Lawrence J Brandt, Joel V Brill, Daniel C Demarco, Marc Alaric Franzos, Colleen Kelly, Alexander Khoruts, Thomas Louie, Lawrence P Martinelli, Thomas A Moore, George Russell, Christina Surawicz
Clinical Gastroenterology and Hepatology 2011, 9 (12): 1044-9
21871249
Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.

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