Effects of dietary consumption of cranberry powder on metabolic parameters in growing rats fed high fructose diets

Ramesh C Khanal, Theodore J Rogers, Samuel E Wilkes, Luke R Howard, Ronald L Prior
Food & Function 2010, 1 (1): 116-23
The effect of dietary consumption of a cranberry powder (CP) containing increased amounts of procyanidins and other phytochemicals on metabolic parameters associated with metabolic syndrome was investigated in growing rats fed a high fructose diet. Dietary treatments were control (starch based), high fructose (HF), and HF containing either 3.3, 6.6, or 33 g CP/kg diet. Fasting plasma glucose and triglycerides tended to be higher with HF feeding and were reduced by feeding CP. The area under curve following an oral glucose tolerance test was 35-50% higher in animals fed HF diet vs. control and was decreased to control levels by the low or medium but not high CP diet. Feeding CP tended to lower fasting plasma insulin. Homeostatic models of insulin resistance (HOMA-IR) and β-cell function (HOMA-BCF) were lowest in animals fed low or medium CP diets (p < 0.05). Rats fed the control starch diet had slightly higher food intake, final body weight, and abdominal fat compared to animals fed other diets. Kidney weight was higher in HF group and feeding CP decreased kidney weight to normal levels. In the fed state, plasma triglyceride was increased with HF diet, whereas insulin was lower in animals fed HF diet. Overall, inclusion of CP in the diet was effective in modulating some aspects of metabolic parameters associated with metabolic syndrome and the medium level of CP in the diet produced a better response than the lower and higher CP levels.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"