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Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin.

Dubert M Guerrero, Christina Chou, Lucy A Jury, Michelle M Nerandzic, Jennifer C Cadnum, Curtis J Donskey
Clinical Infectious Diseases 2011 August 2
In a prospective study of 132 patients with a diagnosis of Clostridium difficile infection (CDI) by polymerase chain reaction, 43 (32%) had enzyme immunoassay (EIA) results negative for toxin. EIA-negative patients with CDI did not differ in clinical presentation from EIA-positive patients and presented a similar risk for transmission of spores.

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