The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study

Jing Zhao, Weibo Xia, Min Nie, Xin Zheng, Qiuping Wang, Xiran Wang, Wenbo Wang, Zhiwei Ning, Wei Huang, Yan Jiang, Mei Li, Ou Wang, Xiaoping Xing, Yue Sun, Lianmei Luo, Shuli He, Wei Yu, Qiang Lin, Yu Pei, Fan Zhang, Youxia Han, Yanmin Tong, Ying Che, Ruixin Shen, Yingying Hu, Xueying Zhou, Ling Xu
Menopause: the Journal of the North American Menopause Society 2011, 18 (11): 1237-43

OBJECTIVE: The aim of this study was to evaluate serum N-aminoterminal propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (β-CTX), and vitamin D status in healthy Chinese postmenopausal women. The study was also designed to investigate their possible relationships with osteoporosis phenotypes.

METHODS: A community-based population of 1,724 postmenopausal women in Beijing was randomly selected. Serum bone turnover markers and 25-hydroxyvitamin D [25(OH)D] were tested by an automated Roche electrochemiluminescence system. Dual-energy x-ray absorptiometry was used to measure bone mineral density (BMD).

RESULTS: The mean (SD) values of serum β-CTX and P1NP were 0.439 (0.210) and 56.7 (27.9) ng/mL, respectively. The 25(OH)D level of postmenopausal women in Beijing was remarkably low (13.2 ± 5.4 ng/mL). Serum β-CTX and P1NP levels were negatively correlated with BMDs of lumbar spine, femoral neck, and total hip (all P < 0.01). The cubic regression model better fitted the relationships of BMD and bone turnover markers. Serum β-CTX levels were significantly higher in women with sustained osteoporotic fracture or vertebral fracture (P = 0.006 and 0.012, respectively). No association between P1NP and fracture or vertebral fracture was detected. The same situation applied to 25(OH)D. 25(OH)D was negatively correlated with β-CTX and P1NP (r = -0.073 and -0.088, P = 0.002 and <0.001, respectively).

CONCLUSIONS: Serum β-CTX and P1NP levels were negatively correlated with BMD. β-CTX was significantly higher in postmenopausal women with sustained fracture or vertebral fracture. Vitamin D deficiency was highly prevalent in postmenopausal women in Beijing.

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