We have located links that may give you full text access.
D-dimer plasma levels in NSTE-ACS patient.
Journal of the Medical Association of Thailand 2011 Februrary
BACKGROUND: Acute Coronary Syndrome (ACS) occurs when a vulnerable plaque ruptures and induces platelet aggregation and coagulation process at the rupture. Thrombogenesis is the final process that forms a clot in the coronary lumen causing myocardial injury. Plasma D-dimer, a primary degradation product and circulating marker offibrin turnover, serves as a direct marker of ongoing fibrinolysis in site of coronary artery occlusion.
OBJECTIVE: To determine the correlation between plasma D-dimer levels and severity of coronary artery obstruction based on angiographic data that is composed of the number of coronary arteries affected and the percentage of maximum stenosis of coronary artery lumen in non-ST elevation ACS (NSTE-ACS) patients.
MATERIAL AND METHOD: NSTE-ACS patients who admitted in Siriraj hospital duringJune 2009 and March 2010 were enrolled. Conditions that increased plasma D-dimer other than NSTE-ACS were excluded. Demographic characteristics were assessed by a standardized questionnaire. Plasma D-dimer was measured and coronary angiography was performed to evaluate severity of coronary artery stenosis.
RESULTS: Total of 74 NSTE-ACS patients were enrolled (29 in unstable angina and 45 in non-ST elevation myocardial infarction). Mean age of these patients (54.1% in female and 45.9% in male) were 66 years. D-Dimer was significantly increased with the number of coronary arteries affected (p = 0.03). In non-significant and single coronary artery disease (CAD) patients, median D-dimer was 406 (178-2,788) mcg/L. In multivessel CAD, median D-dimer was 941 (131-7,110) mcg/L. D-dimer levels had a trend to be increased with percentage of maximum stenosis of coronary artery lumen; atheromatosis, (p = 0.30). In mild and moderate atheromatosis (coronary artery stenosis < 70%), median D-dimer was 479 (182-5902) mcg/L while median D-dimer was 789 (131-7110) mcg/L in severe atheromatosis (coronary artery stenosis > 70%). Moreover plasma D-dimer levels correlated with complication of NSTE-ACS (Congestive heartfailure; p < 0.001, arrhythmia; p = 0.007 and death; p = 0.009) and was increased in patients who underwent treatment with CABG more often than those who received PCI and medication treatment alone. D-dimer also correlated with serum creatinine (r = 0.517, p < 0.001), creatinine clearance (r = -0.463, p < 0.001), troponin-T level (r = 0.381, p < 0.001) and left ventricular ejection fraction (r = -0.368, p = 0.002).
CONCLUSION: D-dimer is useful coagulation marker use to evaluate extent of coronary affected and may predict in-hospital CV complication. However, other conditions that increased plasma D-dimer also excluded.
OBJECTIVE: To determine the correlation between plasma D-dimer levels and severity of coronary artery obstruction based on angiographic data that is composed of the number of coronary arteries affected and the percentage of maximum stenosis of coronary artery lumen in non-ST elevation ACS (NSTE-ACS) patients.
MATERIAL AND METHOD: NSTE-ACS patients who admitted in Siriraj hospital duringJune 2009 and March 2010 were enrolled. Conditions that increased plasma D-dimer other than NSTE-ACS were excluded. Demographic characteristics were assessed by a standardized questionnaire. Plasma D-dimer was measured and coronary angiography was performed to evaluate severity of coronary artery stenosis.
RESULTS: Total of 74 NSTE-ACS patients were enrolled (29 in unstable angina and 45 in non-ST elevation myocardial infarction). Mean age of these patients (54.1% in female and 45.9% in male) were 66 years. D-Dimer was significantly increased with the number of coronary arteries affected (p = 0.03). In non-significant and single coronary artery disease (CAD) patients, median D-dimer was 406 (178-2,788) mcg/L. In multivessel CAD, median D-dimer was 941 (131-7,110) mcg/L. D-dimer levels had a trend to be increased with percentage of maximum stenosis of coronary artery lumen; atheromatosis, (p = 0.30). In mild and moderate atheromatosis (coronary artery stenosis < 70%), median D-dimer was 479 (182-5902) mcg/L while median D-dimer was 789 (131-7110) mcg/L in severe atheromatosis (coronary artery stenosis > 70%). Moreover plasma D-dimer levels correlated with complication of NSTE-ACS (Congestive heartfailure; p < 0.001, arrhythmia; p = 0.007 and death; p = 0.009) and was increased in patients who underwent treatment with CABG more often than those who received PCI and medication treatment alone. D-dimer also correlated with serum creatinine (r = 0.517, p < 0.001), creatinine clearance (r = -0.463, p < 0.001), troponin-T level (r = 0.381, p < 0.001) and left ventricular ejection fraction (r = -0.368, p = 0.002).
CONCLUSION: D-dimer is useful coagulation marker use to evaluate extent of coronary affected and may predict in-hospital CV complication. However, other conditions that increased plasma D-dimer also excluded.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app