How clinical trials really work rethinking research ethics

Debra A DeBruin, Joan Liaschenko, Anastasia Fisher
Kennedy Institute of Ethics Journal 2011, 21 (2): 121-39
Despite prevalent concerns about the ethical conduct of clinical trials, little is known about the day-to-day work of trials and the ethical challenges arising in them. This paper reports on a study designed to fill this gap and demonstrates a need to refine the oversight system for trials to reflect an understanding of this day-to-day work. It also illuminates ethical challenges that cannot be addressed by the oversight system and so necessitate a rethinking of the ethics of clinical trials.

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