The missing C-17 O-methyltransferase in geldanamycin biosynthesis

Min Yin, Tao Lu, Li-Xing Zhao, Yihua Chen, Sheng-Xiong Huang, Jeremy R Lohman, Li-Hua Xu, Cheng-Lin Jiang, Ben Shen
Organic Letters 2011 July 15, 13 (14): 3726-9
The biosynthetic gene clusters for the Hsp90 inhibitor geldanamycin (GDM, 1) have been cloned previously from three different Streptomyces strains, but the gene encoding the C-17 O-methyltransferase remains unknown. The cloning and sequencing of a new GDM biosynthetic gene cluster from Streptomyces autolyticus CGMCC 0516 was reported, identifying the gdmMT gene that encodes the missing C-17 O-methyltransferase for 1 biosynthesis.

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