Arterial stiffness and carotid intima-media thickness in HIV infected patients

Anamaria Papita, Adriana Albu, Daniela Fodor, Corina Itu, Dumitru Cârstina
Medical Ultrasonography 2011, 13 (2): 127-34

BACKGROUND: Cardiovascular disease is an increasing cause of morbidity and mortality in HIV-infected patients. The increased cardiovascular risk is linked to traditional risk factors for atherosclerosis but also, to HIV infection itself which can damage the arterial wall and the antiretroviral therapy (ART) implicated in metabolic disturbances. The aim of our study was to identify the effects of HIV and ART on carotid artery intima-media thickness (C-IMT) and on arterial stiffness, parameters which are used for the evaluation of cardiovascular risk.

PATIENTS AND METHODS: A cross-sectional case-control study of 63 HIV-infected patients (56 exposed to ART, 7 ART naive) and 36 controls matched for age and sex was performed. C-IMT, and arterial stiffness were measured ultrasonographically using an ALOKA ProSound α 10 echo-device. Parameters of arterial stiffness were measured at the common carotid and brachial arteries.

RESULTS: HIV-infected patients had a greater C-IMT than controls (p<0.01). There were significant differences regarding arterial stiffness parameters in HIV infected patients compared to controls, and between the groups of patients with different types of ART, especially at the level of carotid artery. Patients with HIV infection had reduced carotid compliance compared to controls (p<0.01). Patients exposed to reverse transcriptase inhibitort (RTI), had increased β stiffness index (p=0.01) and carotid PWV (p=0.02) and reduced carotid compliance (p<0.01) compared to controls.

CONCLUSIONS: HIV infection and ARV treatment is associated with increased C-IMT, and an increase in the arterial stiffness of the large arteries. These vascular modifications are possible causes of increased cardiovascular risk observed in HIV infected patients.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"