JOURNAL ARTICLE
REVIEW

TLRs as pharmacological targets for plant-derived compounds in infectious and inflammatory diseases

Xin Liu, Jiang Zheng, Hong Zhou
International Immunopharmacology 2011, 11 (10): 1451-6
21586344
Toll-like receptors (TLRs) are generally involved in host immune responses against microbial invasions. Dysfunction of TLRs is closely related to infectious and inflammatory diseases, for which therapeutic manipulation with TLRs agonists and antagonists represent a promising drug strategy. Medicinal plants were used traditionally for the prevention and treatment of infectious and inflammatory diseases. Active compounds derived from these plants were also found with unique features as TLRs agonists and antagonists. These findings bring about new hopes for the application of these naturally existed TLRs modulators. They also provide evidences encouraging further research work of continued characterization for these compounds, which will become promising drug candidates in TLRs-based therapy in the future.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
21586344
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"