Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome

Hikaru Doi, Kimiyoshi Arimura, Yasumasa Ohyagi, Jun-Ichi Kira
Internal Medicine 2011, 50 (10): 1113-5
A 25-year-old woman complained of numbness of the extremities, following muscle rigidity and tenderness. The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. Twenty-seven months after the first symptom, she developed a pricking pain sensation in the lateral left foot, and then gradually developed a purple skin lesion resembling frostbite. The lesion completely disappeared 2 days later. An incidental episode occurred at the same site 8 months later. Frostbite-like skin lesions may be a rare autonomic manifestation in Isaacs' syndrome.

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