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JOURNAL ARTICLE

Hypertension in pheochromocytoma: characteristics and treatment

Samuel M Zuber, Vitaly Kantorovich, Karel Pacak
Endocrinology and Metabolism Clinics of North America 2011, 40 (2): 295-311, vii
21565668
Pheochromocytoma is a tumor of the chromaffin cells in the adrenal medulla and sympathetic paraganglia, which synthesizes and secretes catecholamines. Norepinephrine, epinephrine, and dopamine all act on their target receptors, which causes a physiologic change in the body. High circulating levels of catecholamines can lead to severe hypertension and can have devastating effects on multiple body systems (eg, cardiovascular, cerebrovascular), and can lead to death if untreated. Although surgical treatment represents the only modality of ultimate cure, pharmacologic preoperative treatment remains the mainstay of successful outcome.

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