Structure and cytotoxicity of diterpenoids from Isodon adenolomus

Wei Zhao, Jian-Xin Pu, Xue Du, Jia Su, Xiao-Nian Li, Jian-Hong Yang, Yong-Bo Xue, Yan Li, Wei-Lie Xiao, Han-Dong Sun
Journal of Natural Products 2011 May 27, 74 (5): 1213-20
Twelve new diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Compounds 9, 13-16, and 21 showed significant inhibitory effects on all five cells, with IC50 values in the range 0.7-9.7 μM.

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